SkinBioTherapeutics PLC (LON:SBTX)

The Microbiome

The microbiome is the genetic material of all the microbes - bacteria, fungi, protozoa and viruses - that live on and inside the human body. The microbiome has essential beneficial functions relevant to supporting life and it is a fundamental component of human physiology. Changes in the microbiome can trigger changes in human cellular activities, resulting in disease or contribute to its progression.

The Human Microbiome

• The human body has around 10X more bacteria within it, and on it than human cells
• The collective name for all the genes in all the bacteria is 'the microbiome'
• The microbiome consists of around 1000,000 genes - humans have around 23,000
• The microbiome has huge potential to change how the body functions

Skinbiotix

SkinBioTherapeutics uses lysates (extracts) of probiotic bacteria that have been shown to:

• Increase the skins barrier integrity by enhancing the formation of multi-protein complexes called 'tight junctions'. Tight junctions seal the space between adjacent gut cells to prevent the passage of toxins, molecules and ions through these spaces
• Protect the Skin from infection by outcompeting harmful pathogens
• Increase the rate of Skin healing in response to injury

Martin Hunt
Non-Executive Chairman

Martin has over 30 years' experience in large multi-nationals, start-ups and public companies with a strong track record of management success and fund raising in the life science sector. His previous roles include CEO of biomaterials company Tissue Science Laboratories plc. Martin is Programme Director of the NIHR translational funding programme Invention for Innovation (i4i) and a member of the NIHR Strategy Board.

Dr Cath O'Neill
Chief Executive Officer

Cath is an accomplished biologist and a leader in human-bacterial interactions. Cath previously founded a specialist dermatology business, Curapel Limited, leading the company through its formation and development stage. As an innovator and expert Cath has worked as an advisor for a number of skincare businesses and brand owners. This includes delivering technology from the lab, through development and onto to new product concepts in partnership with global corporations. Cath is a biochemist by training and has previously led research teams as a senior lecturer at the University of Manchester.

Doug Quinn
Chief Financial Officer

Doug has spent the last 15 years involved in start-up and early stage businesses helping to manage them through subsequent levels of growth and secure the requisite funding. Doug has operational experience both within finance and across other business functions as well as considerable corporate finance experience, including in public markets. He was previously CFO at AIM listed Arthro Kinetics Plc and is currently CFO with regenerative medicine company Videregen and prior to joining Skin Biotherapeutics was CFO with University of Manchester spinout Gelexir Healthcare.

Stephen O'Hara
Non-Executive Director

Stephen O'Hara spent 20 years working for the National Health Service (NHS) where he was responsible for delivering microbiology services to a large university teaching hospital. Stephen left the NHS in 2000 to set up an internet auction house, Acolyte Biomedica Limited (Acolyte), which developed rapid diagnostics for healthcare acquired infections such as MRSA. Acolyte was sold to 3M in 2007 where Stephen became Director of Microbiology. Stephen left 3M in 2009 to become a Director at Taunton and Somerset Foundation Trust. In 2011 he founded Intelligent Biotech Limited as a vehicle to identify technologies and market opportunities in healthcare, which has enabled him to identify the emerging potential of the human microbiome and set up OptiBiotix. During over 30 years in microbiology and healthcare, Stephen has authored over 40 articles, including chapters in several books, and is the inventor on a number of patents. He has at various times been editorial referee for the Journal of Medical Pathology and Journal of Clinical Microbiology.

Dr Cathy Prescott
Non-Executive Director

Cathy has over two decades of experience in research, management and business in the biotechnology, pharmaceutical and venture capital sectors. Founder/Director of the consultancy Biolatris Ltd., non-executive Director Videregen Ltd., chair of the Trakcel Ltd Advisory Board, Translation Advisory Group member Babraham Institute and Member of the Board of Trustees IMET2000. She is also a visiting professor at Kings College (London) teaching on the MSc programme 'Cellular Therapies from bench to market' and Senior Associate for the Masters in Bioscience Enterprise (Cambridge University).

Significant Shareholders

As at 24th April 2018, significant shareholders that hold more than 3% of the share capital of SkinBioTherapeutics plc, and shareholdings of any other directors are detailed below:

Director Shareholders

*Martin Hunt's shareholding is held through Invictus Management Limited, a company controlled by Mr Hunt. Of the 466,667 shares held by Invictus Management Limited 22,223 are held in trust for Louise Hunt and 22,222 are held in trust for Oliver Hunt.

SkinBioTherapeutics PLC
15 Silk House
Park Green
Macclesfield
Cheshire
SK11 7QJ

0161 468 2760
[email protected]

Registered Office

SkinBioTherapeutics plc
15 Silk House
Park Green
Macclesfield
SK11 7QJ
United Kingdom
+44 (0)161 4682 760

Nominated Adviser

Cairn Financial Advisers LLP
Cheyne House, Crown Court
62-63 Cheapside
London
EC2V 6AX
United Kingdom
+44 (0)20 7213 0880

Broker

Northland Capital Partners Limited
40 Gracechurch Street
London
EC3V 0BT
United Kingdom
+44 (0)20 3861 6625

Financial PR

Instinctif Partners
65 Gresham Street
London
EC2V 7NQ
United Kingdom
+44 (0)20 7457 2020

Registrar

Share Registrars Limited
The Courtyard
17 West Street
Farnham
GU9 7DR
United Kingdom
+44 (0)1252 821 390

Accountants and Auditors

Jeffreys Henry LLP
Finsgate 
5-7 Cranwood Street
London
EC1V 9EE
United Kingdom
+44 (0)20 7309 2222

Solicitors to the Company as to English law

Turner Parkinson LLP
Hollins Chambers
64a Bridge Street
Manchester
M3 3BA