Psyched Wellness (CSE:PSYC, OTCQB:PSYCF) Ltd said KGK, a contract research organisation, has reported key recent findings from the analysis of intestinal epithelial immune receptor expression in a study performed in conjunction with the 90-day oral toxicity study with Amanita Muscaria Extract (AME-1).
The in vivo study via oral supplementation with AME-1 focused on the potential bioactive effects on the immune receptors Toll-like Receptor-2 (TLR-2) and Dectin-1, which are found on the surface of gut epithelial cells and are useful in fighting pathogens.
"The importance of these in vivo findings indicates an innate immune priming biological activity, and this is preserved during the 90-day study. The potential priming effect and maintenance result in a more efficient response to an invading pathogen, thus promoting greater gut health and increased health and wellness of the individual," Brian Tancowny, a scientific advisor for Psyched Wellness said in a statement.
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"There was no over stimulation or negative effects with long -term use of AME-1 in terms of gut health and wellness. This is another key finding in the further understanding of the effects of AME-1 on health and wellness," he added.
The company said while the recent results reported by KGK showed only a modest increase in TLR-2 and Dectin-1 receptors, this was not a significant finding.
It suggested that the finding could be interpreted as showing the challenge of continuous dosing of AME-1 resulted in maximal cell surface expression of TLR-2 and Dectin-1, thus seeing only a modest positive upregulation of cell surface membrane expression.
“However, the sustained upregulation of both TLR-2 and Dectin-1 receptors indicates innate immune mechanisms that were primed and maintained throughout the course of the 90-day oral study. Furthermore, there was no downregulation of either surface receptor type, nor was there any over priming or stimulating effect which would have negatively impacted the immune system through the production of pro-inflammatory cytokines,” the company said.
Psyched Wellness is a health supplements company dedicated to the distribution of mushroom-derived products and associated consumer packaged goods. It is in the process of developing a line of Amanita Muscaria-derived water-based extracts, teas and capsules designed to promote stress relief, relaxation and assist with restful sleeping.
Contact the author at jon.hopkins@proactiveinvestors.com