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Pharma & Biotech

ANGLE technology used in metastatic breast cancer research

The Parsortix system was used to help scientists understand the cause of the spread of breast cancer to other organs, and also, how this process, called metastasis, might be slowed or halted

ANGLE PLC (AIM:AGL, OTCQX:ANPCY) said its liquid biopsy system was central to research carried out by scientists attempting to understand why breast cancer spreads, a process called metastasis.

The Parsortix system was used by members of the molecular oncology lab at the Swiss Federal Institute of Technology in Zurich to identify circulating tumour cells (CTCs) and CTC clusters.

Clusters are associated with a 23 to 50-fold increased potential to spread compared to single CTCs and therefore are linked to a higher risk of death in metastatic breast cancer (MBC) patients.

ANGLE chief executive Andrew Newland said: "We are pleased to report on the use of the Parsortix system for the isolation of single CTCs and CTC clusters in preclinical MBC models, allowing the identification of actionable targets involved in cancer metastasis.

“ANGLE's ability to provide such actionable insight shows potential to guide targeted drug development, which can be achieved through our growing pharma services business."

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