Avalon GloboCare Corp (NASDAQ:AVCO). has successfully co-developed a novel platform of S-layer coated emulsome technology (SLET) for next-generation drug delivery and cellular immunotherapy.
Avalon said it has partnered with Professor Uwe Sleytr of the University of Natural Resources and Life Sciences (BOKU) in Vienna to develop the SLET platform. And both have jointly filed US and international PCT patent applications for the novel SLET platform.
Avalon noted that, as a vesicular nano-carrier system, emulsomes are composed of an internal lipoidal core surrounded by phospholipid multilayers.
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This emulsome nano-carrier, when loaded with bio-active agents (such as poorly water-soluble pharmaceuticals and genetic materials, including DNA and RNA), may increase their solubility and bioavailability. This nano-formulation is also designed to be safe and nontoxic.
Avalon said the SLET platform exploits the S-layer fusion proteins as coating materials for the emulsome nano-carriers in order to provide a “molecular GPS system” to guide the trafficking and delivery of the emulsomal payload to a targeted destination in the body.
Avalon noted that is actively exploring the practical uses of SLET, including targeted drug delivery, vaccine development, diagnostic devices, and cellular therapeutic applications.
“We are very excited to announce this novel SLET platform, which we believe will help accelerate the development of our mRNA-based Flash-CAR program,” said Avalon CEO Dr David Jin in a statement.
“The targeted delivery of mRNA to immune effector cells by SLET could open the door to a whole new generation of cancer immunotherapy. In addition, we see a number of other therapeutic and diagnostic applications for this broad and potentially transformative technology platform. Moreover, we believe these latest patent filings will provide us robust international IP protection for this technology and its many potential applications.”
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