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Pharma & Biotech

Evgen Pharma says latest data points to the potential of drug candidate to inhibit a range of cancers

The latest research was carried out by Professor Philip Eaton, of Queen Mary University of London

Evgen Pharma PLC (LON:EVG) said its lead compound has been shown to inhibit a protein associated with a number of different cancers.

Research carried out by Professor Philip Eaton, of Queen Mary University of London, showed SFX-01 was able to decrease the activity of SHP2.

This is a non-receptor protein tyrosine phosphatase that is associated with breast cancer, leukaemia, lung cancer, liver cancer, gastric cancer, laryngeal cancer and oral cancer.

"SHP2 has been a target of some interest for a while, but to date attempts to develop an inhibitor have had limited success,” said Evgen chief executive, Dr Huw Jones in a statement.

“We are delighted that the data generated by Professor Eaton demonstrates that SFX-01 acts on SHP2 in a novel manner and offers the potential for its use in a number of cancers with great clinical need."

The latest data follows hard on the heels of another pre-clinical landmark, which suggested SFX-01 could also potentially provide a potent treatment for glioma and glioblastoma.

Evgen is developing medicines based on sulforaphane, a sulfur-rich compound found in vegetables such as broccoli, bok choy, and cabbage.

Its core technology is Sulforadex, a method for synthesising and stabilising the naturally occurring compound.

The group's lead product, SFX-01, is a patented composition of synthetic sulforaphane and alpha-cyclodextrin.

Evgen has successfully completed a phase IIa trial of its drug in women with certain forms of advanced breast cancer.

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