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Scancell adds six ‘world-leading’ cancer specialists to advisory board ahead of Modi-1 trial

“The initial focus of the board will be to inform the clinical strategy for the planned Modi-1 clinical trial and to ensure the best possible outcome in several solid tumour indications”
cancer patient
Modi-1 is due to enter the clinic in the first quarter of 2020

Scancell Holdings PLC (LON:SCLP) has added six “world-leading” cancer specialists to its clinical advisory board as the drug developer prepares for its Modi-1 cancer treatment to enter the clinic early next year.

AIM-quoted Scancell’s clinical advisory boards now boasts some of the brightest and most respected cancer researchers that the UK has to offer.

READ: Scancell to begin UK arm of skin cancer trial within weeks

The University of Sheffield’s emeritus professor of medical oncology, Robert Coleman, is joined by Christian Ottensmeier, a professor of experimental cancer medicine treatment at the University of Southampton.

Imperial College London professor of oncology, Iain McNeish, Mount Vernon cancer centre’s lead breast cancer clinician David Miles, Nottingham University Hospital’s Stephen Chan and Poulam Patel, professor of clinical oncology at the University of Nottingham, have also joined the board.

“We are delighted to welcome all six experienced clinicians to our clinical advisory board and the creation of this Board is part of our wider strategy to fully develop and deliver the full potential of the Moditope platform across multiple tumour types,” said Scancell chief executive Cliff Holloway.

“The initial focus of the board will be to inform the clinical strategy for the planned Modi-1 clinical trial and to ensure the best possible outcome in several solid tumour indications, including ovarian cancer, head and neck cancer, and triple negative breast cancer.”

‘Significant progress’ made

Modi-1 is Scancell’s first drug using its Moditope technology. It acts to stimulate the production of killer CD4+ T cells that seek out and kill tumour cells which would otherwise be hidden from the immune system. 

A phase I/II study is set to begin in the first quarter of 2020, which will see Modi-1 trialled in patients with various types of cancer, including head and neck, breast and ovarian.

Scancell confirmed on Friday that preparation for the trial is well underway. A Scottish firm has now been chosen to manufacture and package the final Modi-1 product, while a preclinical toxicity testing programme got underway last month and is expected to be wrapped up later this year.

Holloway added: “Significant progress has been made towards completing the GMP manufacture of the Modi-1 product and the preclinical testing required prior to the anticipated start of the trial early in 2020.”

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