Avacta Group PLC

Analysts eye more licensing deals for Avacta’s Affimer technology in 2019


Avacta is using Affimers to develop its own cancer therapy, but it also licenses the technology to other companies, including major pharma group ModernaTX and LG Chem Life Sciences


Quick facts: Avacta Group PLC

Price: £0.21

Market: AIM
Market Cap: £24.39 m
  • Makes Affimers, which are similar to antibodies

  • Using its technology to develop its own cancer treatment

  • First in-human trials for that therapy slated for next year

  • Also licenses its technology to other biophmars


What it does

Biotech Avacta Group PLC (LON:AVCT) has developed a protein-scaffold platform, with potential applications in the life sciences research, diagnostic and therapeutics markets.

Avacta’s scaffolds are called Affimers, which are essentially small, engineered proteins capable of binding specific molecular targets, in a similar way to antibodies.

This binding property can be used to target cancer cells in the human body and make those cells vulnerable to attack from the body’s own immune system.

Many existing immuno-oncology therapies use an antibody to target cancer, but Affimers have several innovative features which potentially make them a better tool for several diagnostic and therapeutic applications.

They are smaller, quicker to manufacture and easier to format, but they maintain antibody-like biologic activity when binding a target.

Avacta is using Affimers to develop various potential cancer treatments, while other companies pay to use the technology in their research and diagnostics.


How it’s doing

Avacta has selected a PD-L1 inhibitor as the first Affimer-based potential cancer therapeutic that it is taking through the clinic.

PD-L1 is a checkpoint protein that essentially provides a cloak for the cancer cells, helping them to evade detection by the immune system.

The company is soon to start manufacturing its PD-L1 inhibitor – called AVA004-251 – which will then allow it to file a clinical trial application, asking regulators to let it test the drug on humans.

READ: Capital Network’s latest Avacta report

That filing is expected to happen in late 2020 and the plan is to start dosing the first patients in a Phase I dose escalation study in the final quarter of next year.

As for the other side of the business, in February, multi-billion-dollar biotech ModernaTX entered into an exclusive licensing agreement to develop certain Affimers against an undisclosed therapeutic target.

That followed on from a similar deal reached with another major player, LG Chem Life Sciences, in December for the development of Affimers for various disease areas.


Blue sky

Analysts agree that the next year or two will be a busy period for Avacta, and a busy pre-clinical biotech normally needs more cash to keep moving forward.

Not Avacta, though. The company had £11.8mln of cash in the bank at the end of January thanks to an £11.6mln fundraise last summer.

Research boutique Capital Network thinks the company can “comfortably” fund itself through to 2020, when the first in-human trials of AVA004-251 are expected to occur.  

Capital Network added: “We believe that it is realistic to expect that further partnerships and licensing agreements could be announced during 2019.”


What the boss says

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events


The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of Avacta Group PLC named herein, including the promotion by the Company of Avacta Group PLC in any Content on the Site, the Company receives from...



Investor Update: Green light for ValiRx to increase dose of VAL201

Top stories from the Proactive Investors UK newsroom. ValirX (LON:VAL) has received a boost for its prostate cancer treatment VAL201 after UK regulators approved a substantial increase in the doses allowed in future clinical trials. The phase I/II trial so far has met all primary and...

on 20/6/19

3 min read