viewC4X Discovery Holdings PLC

C4X Discovery upbeat on finding next partnership deal


  • Chief executive Clive Dix appointed as interim  chair of UK Vaccine Taskforce
  • Has a software-based rapid discovery platform 
  • Deal with Indivior worth £227mln in milestone payments



Quick facts: C4X Discovery Holdings PLC

Price: 38 GBX

Market: AIM
Market Cap: £86.01 m

What C4X does

C4X Discovery Holdings plc’s (LON:C4XD) stated aim is to become the world’s most productive drug discovery engine.

To achieve this goal it is using cutting-edge technologies and expertise to efficiently deliver small-molecule (pharmaceutical) medicines.

It has a unique software platform for determining the flexible 3D shapes of drug molecules from experimental data.

This enables the rapid design and discovery of novel and potent drugs for diseases with high unmet medical need across broad therapeutic areas.

Unlike many drug companies, it looks to find partners at the pre-clinical phase, allowing big pharma to fund expensive human trials.

It successfully out-licensed its programme for addictive disorders to Indivior, receiving an upfront £7.7mln (US$10mln) and milestones of £227mln (US$294mln).

It is working on potential treatments for Parkinson’s, Alzheimer’s and inflammatory bowel disorders and it has numerous collaboration deals.

Below is the company’s drug pipeline


How it is doing

FTSE 250-listed drug group Indivior has taken C4X’s treatment for opioid use disorder into the clinic as part of a deal worth US$294mln. Phase I and II studies will receive financial backing from the National Institutes of Health in the US.

C4X also began a new partnership with the GEN-COVID Consortium in Italy to deploy C4X’s Taxonomy3 platform technology to examine genetic data from COVID-19 patients to identify genes specifically associated with severe types of the disease.

The AIM-listed group is looking for partners in programmes ongoing in bowel inflammation, psoriasis, MALT1 deficiency and COVID-19.

Clive Dix, chief executive, is also interim chair of the UK Vaccines Task Force.

What the boss says: Clive Dix, chief executive

"2020 has also been a year of significant and focused progress for C4XD as we continue to advance our key Drug Discovery programmes within our portfolio.

“With robust finances now in place, we are strongly positioned to generate commercially attractive data packages for future partners.”


Inflexion points

  • Clinical trial for the Orexin-1 programme with Indivior
  • A partner for the NRF-2 activator programme with the company seeing commercial interest
  • Partnership with the GEN-COVID Consortium for COVID-19 patients

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C4X Discovery Holdings says strong progress across the portfolio as...

C4X Discovery Holdings PLC's (LON:C4XD) chief executive Clive Dix talks to Proactive London about taking over as the interim chair of the UK Vaccine Taskforce following the departure of Kate Bingham. Dix goes on to discuss how this appointment will impact C4X, explaining "if you look at what...

on 10/12/20

2 min read