Proactive Investors - Run By Investors For Investors

Faron to target colorectal cancer patients in ongoing Clevegen study after early promise

Faron has recruited four people to its trial, and although all of them have reacted well to the drug so far, the colorectal cancer patient has seen the most dramatic response
colorectal cancer
Metastasis is when the cancer spreads from the primary site to another part of the body

Faron Pharmaceuticals Ltd (LON:FARN) is to target more patients with late-stage colorectal cancer as part of the ongoing phase I/II study of its Clevegen immunotherapy drug.

Cancer cells are notoriously good at evading detection by the immune system, but Clevegen has been designed to recognise the tumour cells and break their protective shell.

READ: Faron Pharma up on cancer trial positive

One of the patients currently enrolled in the trial has the most common form of colorectal cancer – called MSI-low – and has seen a “significant shrinkage” in lung metastasis.

That person, who has been treated with six other treatments in the past without success, has also shown further signs of their immune system starting to get to grips with the disease.

Although the three other patients have also reacted well to Clevegen so far and demonstrated an ‘immune switch’, Faron wants to narrow its focus on MSI-low colorectal patients going forward.

Most likely to respond

“With this patient demonstrating a clinical partial response and expected immune switch, Faron is confident it has identified one group of patients who are thought to most likely respond to treatment and demonstrate an immune switch in these immunosuppressive Clever-1-positive tumour associated macrophages (TAMs).”

MSI-low colorectal patients represent around 90% of all colorectal cancers and there are over one million new cases of the disease around the world every year.

More of those patients will be enrolled into the trial once Faron has figured out the optimal dose of Clevegen.

It has given the four recruited subjects doses of 0.3mg/kg and 1.0mg/kg without any problems, and it has now upped this to 3.0mg/kg.

Assuming that is also well tolerated, the plan is to move up to 10.0mg/kg, which will be the maximum dose.

Boss 'encouraged' by early data

“We are encouraged by the data gathered so far from the MATINS study, particularly the tumour imaging report from a colorectal patient in whom all other treatments have failed, which demonstrates a partial response according to RECIST already in nine weeks,” said chief executive Markku Jalkanen.

“This information further supports our belief that Clevegen has the ability to function as a novel macrophage checkpoint immunotherapy for patients with currently untreatable solid cancers.”

He added: “Advancing MATINS into the cohort expansion stage later this year indicates our commitment to rapidly advance the development of this potential therapy for patients in need of new treatment options.”

View full FARN profile View Profile

Faron Pharmaceuticals Ltd Timeline

Related Articles

Empty lab
September 19 2018
Management has made some tough decisions, cutting the cost base, since a disappointing first-half performance and expects the benefits to really kick in next year
seeds in a bowl
March 07 2019
The Vancouver company is developing Omega-3 products as oil, powder or emulsion to be used as food additives
Cyrptocurrencies
June 27 2018
Lancor Scientific is aiming to carry out an initial coin offering by issuing Medici, a new currency based on Ethereum to help Tumour Trace to fund further development

© Proactive Investors 2019

Proactive Investors Limited, trading as “Proactiveinvestors United Kingdom”, is Authorised and regulated by the Financial Conduct Authority.
Registered in England with Company Registration number 05639690. Group VAT registration number 872070825 FCA Registration number 559082. You can contact us here.

Market Indices, Commodities and Regulatory News Headlines copyright © Morningstar. Data delayed 15 minutes unless otherwise indicated. Terms of use