Proactive Investors - Run By Investors For Investors

AstraZeneca’s Imfinzi cancer drug fails in another late-stage trial

The drug failed to prolong the lives of patients with advanced head and neck cancers when it was used alone or in combination with another treatment, in comparison to standard chemo
head x ray
Imfinzi has so far struggled to treat late-stage cancers

One of AstraZeneca PLC’s (LON:AZN) key new drugs Imfinzi has failed in yet another late-stage clinical trial, this time in advanced head and neck cancer.

The drug was tested both on its own and in combination with tremelimumab but neither improved overall survival any more than standard chemotherapy.

“While these results are disappointing, we remain committed to evaluating the potential of Imfinzi and other innovative medicines for patients with head and neck cancer,” said chief medical officer Sean Bohen.

“We look forward to seeing the results of the phase III KESTREL trial of Imfinzi and tremelimumab in patients who have not received prior chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma in the first half of 2019.”

READ: AZN in cancer drug setback

Imfinzi is one of AstraZeneca’s potential star assets and had been expected to generate annual sales of more than US$2.5bn from 2022.

It has previously been approved for use in earlier stage lung cancer the cant be removed without surgery, and AstraZeneca has been carrying out further trials that may support its use in other indications.

But the drug has now failed two late-stage trials in less than a month. On top of today’s disappointed, it also failed to prolong the lives of patients with advanced lung tumours.

Imfinzi’s failure in treating late-stage cancer patients, along with other setbacks, will make it difficult for the FTSE 100 group to hit the US$40bn of sales its chief executive Pascal Soriot had promised to achieve by 2023.

Astra shares were broadly unchanged at 5,950p in early deals on Friday.

View full AZN profile View Profile

AstraZeneca Timeline

Article
November 16 2018

Related Articles

blood
December 03 2018
Feraccru already has EU approval while in Switzerland the drug can be used for iron deficiency anaemia in adults with inflammatory bowel disease
researcher filling a tray of samples
December 14 2018
The company has two clinical trials underway and is well funded to achieve its immediate ambitions
Empty lab
September 19 2018
Management has made some tough decisions, cutting the cost base, since a disappointing first-half performance and expects the benefits to really kick in next year

© Proactive Investors 2019

Proactive Investors Limited, trading as “Proactiveinvestors United Kingdom”, is Authorised and regulated by the Financial Conduct Authority.
Registered in England with Company Registration number 05639690. Group VAT registration number 872070825 FCA Registration number 559082. You can contact us here.

Market Indices, Commodities and Regulatory News Headlines copyright © Morningstar. Data delayed 15 minutes unless otherwise indicated. Terms of use