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The Markets
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Pharma & Biotech

UBS reckons Tagrisso will be worth more than US$5bn a year to AstraZeneca by 2022

Tagrisso sales look like they will beat expectations over the coming years, but UBS has concerns that the future profits drag brought about by externalisation deals hasn’t been properly factored into estimates yet

AstraZeneca PLC (LON:AZN) shares nudged higher on Monday morning after UBS hiked its price target for the UK drugs giant.

Analysts at the Swiss bank reckon the current consensus for sales of Tagrisso – Astra’s lung cancer drug which was approved by US and European regulators last year – are too low.

“We forecast US and global Tagrisso sales of US$2.5b and US$5.8b in 2023; 47% and 41% ahead of recent company collated consensus, respectively,” said Jack Scannell in a research note.

READ: AstraZeneca’s “remarkable” pipeline turnaround

The analyst upped his 2026 full-year earnings per share estimate by almost 14% as the drug’s high margin sales flow through.

To fund its recent pipeline resurgence, AstraZeneca has been selling off the rights to some of its non-core assets for an upfront fee, something called an ‘externalisation’ deal.

This generally involves selling a drug for an upfront fee and therefore missing out on future profits, the impact of which UBS doesn’t think has been properly accounted for in the market’s estimates.

“[Our] second analysis looks at Externalisation Revenue (ER) & Other Operating Income (OOI),” wrote Scannell.

“It suggests that consensus under-estimates the future profits that are forgone when Astra trades them for up-front payments.

“If one assumes consensus is right from '18 to '23 on cumulative up-front payments, then forgone run-rate profits could be a 9% drag on operating profit by 2024, before declining.”

TP up, rating still ‘neutral’

The analyst reckons the better-than-expected Tagrisso sales should more than even out the drag on future profits by externalisation deals.

“Hence we maintain our ‘neutral’ rating.” As for his 12-month target price, Scannell upped that to 5,600p from 4,550p.

Astra shares crept 0.6% higher to 5,262p on Monday morning.

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