AstraZeneca receives more solid data for its Imfinzi lung cancer treatment

Imfinzi showed a “statically-significant” benefit to overall survival in patients with unresectable stage III non-small cell lung cancer

Imfinzi had already been approved by the FDA for use in this subset of patients earlier this year

AstraZeneca PLC (LON:AZN) has received some more positive trial data for its Imfinzi cancer treatment.

Imfinzi – sometimes referred to as durvalumab – is what’s called a checkpoint inhibitor which binds onto a tumour cell to stop it tricking the immune system into thinking it is a ‘good’ cell.

READ: Third time lucky for AstraZeneca and its Lokelma hyperkalaemia treatment

The drugs giant said on Friday that the treatment met the second of two primary endpoints in the phase III PACIFIC trial, showing a “statistically-significant” benefit to overall survival in patients with unresectable stage III non-small cell lung cancer (NSCLC) whose disease hadn’t improved after a course of chemotherapy and radiation therapy.

Astra added that there was a “clinically-meaningful improvement” in patients receiving Imfinzi compared to those on the placebo.

The drug met the other primary endpoint of progression free survival (PFS) earlier this year, on which basis it was approved for use in this subset of lung cancer patients in the US.

“Given the aforementioned positive PFS and approval in place already, today's news makes limited difference to the product's potential but does remove the (v low) risk that a failed OS endpoint undermines AZ's position in the indication,” wrote Liberum analyst Roger Franklin in a research note.

“However, it will likely be taken positively given this is early versus the final OS analysis wasn't due until 2019.”

Astra shares opened 0.9% higher at £54.78.

Quick facts: AstraZeneca

Price: 7217 GBX

Market: LSE
Market Cap: £94.68 billion

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events


The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...



Things coming together nicely in Greenland, says Bluejay Mining's CEO

Rod McIllree, Bluejay Mining PLC’s (LON:JAY) chief executive, tells Proactive that all three of its projects in Greenland are shaping up nicely with plenty of interest from mining giants. Dundas is the flagship and here a bulk sample of mineral sands has been shipped to a Rio Tinto facility...

2 days, 15 hours ago

2 min read