Kicking off with the pharma space, where Med-tech firm ANGLE (LON:AGL) has passed a major milestone by making its first sale of its breakthrough Parsortix system, which is able to detect tiny circulating tumour cells that provide tell-tale signs of cancer.
No financial details were given, but the AIM-listed innovator did said the deal had been struck to use the technology in research.
Elsewhere, Motif Bio (LON:MTFB) revealed clinical trial supplies in the form of sterile ampoules of its iclaprim antibiotic have been manufactured.
Following quality assurance release, the supplies will be shipped to clinical trial sites, where tests will assess iclaprim in cases of acute bacterial skin and skin structure infections (ABSSSI).
Meanwhile, ImmuPharma (LON:IMM) was host to 70 investigators and senior coordinators from the US and Europe who will be involved in the pivotal phase-III trial of Lupuzor, a potentially breakthrough treatment for the auto-immune disease Lupus.
To resources – where Hummingbird Resources’ (LON:HUM) first reserves statement for its Yanfolila gold project in Mali has confirmed its low cost potential according to its chief executive.
The explorer said Komana East and West, the first pits to be mined under the current plan, had gross maiden probable reserves of 6.82Mt at a grade of 3.03 g/t or the equivalent of 665,600oz gold.
Away from gold, shares in Mexico-focused Arian Silver (LON:ACQ CVE:ACQ) began trading on AIM again this morning having been suspended since October 29 as discussions over financing continue.
Staying with precious metals, Jubilee Platinum (LON:JLP) signed off its tailings treatment contract to produce platinum from Hernic's ferrochrome waste dumps in South Africa.
Elsewhere in the mining sector, Weatherly International (LON:WTI) upped the copper reserve estimate at its Tschudi mine, in Namibia, as it continues to slash costs and ramp up production.
Sapphire miner Richland Resources (LON:TLD) said non-executive director Nicholas Sibley has increased his stake in the company.
Paragon Diamonds (LON:PRG) is to negotiate directly with the Government of Lesotho to keep its proposed acquisition of the Mothae kimberlite resource alive.
IronRidge Resources (LON:IRR) has unearthed a high-grade Direct Shipping Ore bauxite deposit at its Monogorilby project in Queensland, Australia.
Cost cutting measures by Uruguay-focused Orosur Mining (LON:OMI, TSX:OMI) are paying off - as it unveiled improved operating metrics in its latest quarter.
In the energy sector, 88 Energy (LON:88E) has confirmed the presence of what it described as persistent oil shows though the HRZ shale formation, the primary target of the Icewine-1 exploration well onshore Alaska.
The result from the ongoing programme will provide encouragement for investors, though more drilling and further detailed analysis is still to come.
Caza Oil & Gas (LON:CAZA) has arranged a US$45mln refinancing that will clear the bulk of its debt but leave existing shareholders with under 3% of the company.
In other news, Utilitywise (LON:UTW) has secured a “favourable” change to payment terms with a second key energy supplier.
Sibley has acquired a total of 300,000 Richland shares at a price of 3p, across two transactions (one on December 4 and one on December 9), the company revealed in a statement.
Finally, tablet and mobile technology specialist Motive Television (LON:MTV) has developed a preliminary version of its TabletTV app for the new Apple Television.