Replimune (NASDAQ: REPL) shares fell nearly 31% on Tuesday after US Food and Drug Administration (FDA) staff reviewers raised concerns over the effectiveness of the company’s lead cancer therapy, RP1, ahead of a key advisory committee meeting.
The decline followed the release of FDA briefing documents that questioned whether Replimune had provided sufficient evidence to demonstrate RP1’s efficacy in advanced melanoma. The stock has now fallen for five consecutive sessions, down about 47% over that period.
Royal Caribbean Cruises Ltd (NYSE:RCL) shares rose 4.4% on Tuesday after the cruise operator beat second-quarter profit estimates and raised its full-year outlook on strong close-in demand and cost efficiencies.
The company posted adjusted earnings per share of $4.21, topping analyst estimates of $3.98, though the figure was down 4% from a year earlier. Revenue came in at $4.8 billion, up 6% year-over-year and just shy of the $4.82 billion analysts had expected.
Hilton Worldwide Holdings Inc (NYSE:HLT) raised its full-year profit outlook on Tuesday, but shares fell 3.4% after third-quarter guidance came in below Wall Street estimates.
The hotel operator now expects full-year adjusted earnings per share of $8.89 to $9.01, up from $8.79 to $8.91 previously.
PayPal Holdings Inc (NASDAQ:PYPL, XETRA:2PP) shares rose almost 4% after the company reported second quarter 2026 results that exceeded Wall Street expectations and raised its full-year non-GAAP guidance.
The payments company reported adjusted earnings of $1.38 per share on revenue of $8.68 billion for the quarter ended June 30, compared with analyst estimates of $1.28 per share and $8.47 billion in revenue.
374Water Inc (NASDAQ:SCWO, FRA:8LL) announced that it has completed Phase 2 of its mobile AirSCWO deployment in St. Cloud, Minnesota, and has begun the third phase of the project as the state continues evaluating the company's technology for the destruction of PFAS-contaminated waste.
The deployment is being carried out under a $600,000 waste destruction services contract with the City of St. Cloud, in partnership with Barr Engineering, at the city's Nutrient, Energy, and Water Recovery Facility. The pilot is part of Minnesota's assessment of AirSCWO technology for destroying PFAS-containing waste streams, with support from the Legislative-Citizen Commission on Minnesota Resources and the state's Environment and Natural Resources Trust Fund.
United Parcel Service Inc (NYSE:UPS) shares fell 6% following its second quarter 2026 earnings report as investors focused on weaker near-term domestic expectations, lower international operating profit and significant restructuring charges despite the company beating quarterly estimates and raising its full-year outlook.
UPS reported adjusted earnings per share of $1.76 for the quarter, ahead of analyst expectations of $1.66, while revenue of $22.8 billion also exceeded estimates of $21.84 billion.
GSK PLC (LSE:GSK, NYSE:GSK) shares jumped to a three-month high after the drugmaker beat second-quarter expectations across its main measures and accelerated investment in its pipeline.
Revenue rose 5% to £8.41 billion, ahead of the £8.25 billion City consensus. Adjusted earnings per share increased 9% to 50.5p, beating the 46.8p forecast by almost 8%.
The Coca-Cola Company (NYSE:KO) reported better-than-expected second quarter results on Tuesday and raised its full-year guidance, sending shares up almost 7% in early trading on Tuesday.
The beverage maker posted adjusted earnings of $0.97 per share for the quarter, ahead of Wall Street estimates of $0.93 per share.
Boeing Co (NYSE:BA, XETRA:BCO) posted a wider-than-expected quarterly loss but beat revenue estimates, as the planemaker's commercial deliveries climbed and its backlog swelled to a record $715 billion.
The company reported second-quarter revenue of $24.6 billion, up 8% from a year earlier and ahead of the $24.25 billion analysts had expected. Adjusted loss per share came in at $0.76, missing the $0.30 loss estimate.
Navitas Semiconductor (NASDAQ: NVTS) shares fell about 10% in premarket trading on Tuesday after investors focused on the company's large GAAP net loss, despite second-quarter revenue topping Wall Street expectations.
The power semiconductor company reported an adjusted loss of $0.04 per share for the second quarter, matching analyst estimates.
Applied Digital Corp (NASDAQ:APLD) reported fourth-quarter revenue of $258.7 million, up 407% from a year earlier, as the company accelerates its shift into a pure-play AI infrastructure developer.
The company posted adjusted earnings of $0.04 per share for the quarter, compared with analyst estimates of a loss of $0.22 per share.