leadf
logo-loader
viewe-Therapeutics PLC

e-Therapeutics bullish on discovery platform

"With the progress we are making both in the clinical programmes and in discovery, we expect another exciting year,"

Bacteria(resistant).png
The final patient has also been enrolled in a US study into brain cancer.
e-Therapeutics (LON:ETX) remains upbeat on its new discovery platform that it said is achieving productivity rates well above the norm.
Molecule selection and testing across seven projects had suggested more than 25% of screened compounds were both active and more potent than any previously reported.
“For example, initial results from our most recent project, which sought potent small molecule inhibitors of TNFα, a major inflammatory cytokine, produced a yield rate of potent molecules above 40%, even after initial toxicity screening,” said acting chairman and chief executive Malcolm Young.
These yield rates are much higher than published rates for conventional drug discovery, he added.
Cytokines are small cells that affect the behaviour of other cells.
In its clinical programmes, e-therapeutics recently dosed its first patient for a Phase 1b trial in pancreatic and hepatocellular cancers.
The final patient has also been enrolled in a US study into brain cancer. This cohort is being dosed at 36 mg/kg with one of the group presently on their seventh cycle at this dose level. 
“Unlike the UK trial, there have been no dose-limiting toxicities determined at the current dosage, although the patients have experienced similar short-term side effects to those observed in the UK,” Young said. 
"With the progress we are making both in the clinical programmes and in discovery, we expect another exciting year, he concluded.
Shares rose 3% to 41p.

 

Quick facts: e-Therapeutics PLC

Price: 14.325 GBX

AIM:ETX
Market: AIM
Market Cap: £60.03 m
Follow

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events

NO INVESTMENT ADVICE

The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of e-Therapeutics PLC named herein, including the promotion by the Company of e-Therapeutics PLC in any Content on the Site, the Company receives...

FOR OUR FULL DISCLAIMER CLICK HERE

Morning Report: FTSE 100 makes early rally as airline losses set to total...

Headlines from the Proactive UK newsroom. The FTSE 100 rallied early on after two days of losses with travel groups leading the way. The blue-chip index was up 30 points at 6,366. Airline losses will total around US$84bn this year according to the International Air Transport Association....

on 10/6/20

2 min read