The FTSE 100 has started Wednesday off on the wrong foot ahead of Donald Trump's reciprocal tariffs announcement later, following a mixed session on Wall Street overnight and in Asian markets this morning.
About 40 minutes into trading, the blue chip index was down 37 points (0.42%) at 8,598.
GSK and AstraZeneca were among the big fallers, echoing a decline in US big pharma names overnight.
Housebuilders were also lower, led by Persimmon, Barratt and Taylor Wimpey.
On the FTSE 250, Raspberry Pi shares are up 3% after it reported its first full-year results following its IPO last June.
And Bakkavor has jumped 5.7% after it agreed to a merger with Greencore Group to create a £4 billion convenience food group.