The stock declined 3% to $73.17.
Bristol-Myers Squibb Co (NYSE:BMY) shares headed south as the drug company withdrew an application to the US Food and Drug Administration for a blockbuster cancer drug combination to allow it to collect more data. It posted a quarterly beat on earnings and revenue.
Shares fell 1.8% to $49.02.
Airlines flew into focus, with Southwest Airlines Co (NYSE:LUV) advancing after beating fourth-quarter estimates. Net income fell to $654 million, or $1.17 per share, from $1.75 billion, or $2.94 per share, a year earlier. But analysts on average had expected a quarterly profit of $1.07 per share.
The stock added 6.3% to $54.22.
The shares added 5.1% to $18.12.
American Airlines Group Inc (NASDAQ:AAL) gained on fourth-quarter earnings per share of $1.04, which topped analysts' estimate of $1.01. Revenue for the quarter came in at $10.94 billion, against the consensus estimate of $10.96 billion.
The stock added 6.4% to stand at $33.66.