Angle PLC - Parsortix outperforms other CTC systems in RCC
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PARSORTIX OUTPERFORMS OTHER CTC SYSTEMS IN RENAL CELL CARCINOMA
Workflow combines Parsortix with downstream process for single cell analysis of each individual cancer cell
The disease is often asymptomatic (few or no symptoms) and about 30% of patients with RCC present with metastatic disease. Their prognosis is poor with an overall 5-year survival rate of less than 20%. A number of targeted therapies have recently become available and a liquid biopsy to determine whether such treatments might benefit individual patients would be highly valuable.
Legacy circulating tumor cell (CTC) antibody-based systems have been ineffective in RCC due to low expression of epithelial markers on the CTCs. Istituto Nazionale Tumori di
The Parsortix system greatly out-performed the alternative approach and, being a marker-independent approach for CTC enrichment, it was described in the publication as being "instrumental for increasing CTC detection and for being able to separately identify the sub-populations by immunostaining".
The pilot study suggested that even the presence of a single CTC in a blood sample prior to treatment may predict a reduced progression free survival.
The research has been published as a peer-reviewed publication in the
"There is a major unmet clinical need in renal cell carcinoma for personalised treatment decisions. We hope that this original work will pave the way for further investigation of how Parsortix can be used to benefit patients with tumor types characterised by low expression of epithelial markers, such as renal cell cancer."
ANGLE Founder and Chief Executive,
"This publication adds to the body of evidence demonstrating the strong advantages of the Parsortix system identifying new potential uses of the system to improve the care of cancer patients."
As previously announced, following a Q-Submission meeting in January with the
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Notes for editors
ANGLE is a world leading liquid biopsy company with sample-to-answer solutions. ANGLE's proven patent protected platforms include a circulating tumor cell (CTC) harvesting technology and a downstream analysis system for cost effective, highly multiplexed analysis of nucleic acids and proteins.
ANGLE's cell separation technology is called the Parsortix® system, and it enables a liquid biopsy (a simple blood test) to be used to provide the cells of interest to the user in a format suitable for multiple types of downstream analyses. The system is based on a microfluidic device that captures cells based on a combination of their size and compressibility. The system is epitope independent and can capture all types of CTCs as well as CTC clusters in a viable form (alive). CTCs enable the complete picture of a cancer to be seen as being a complete cell they allow DNA, RNA and protein analysis and the live cells harvested can be cultured. The Parsortix technology is the subject of 24 granted patents in
ANGLE's technology for the multiplex evaluation of proteins and nucleic acids of all types is called the HyCEADTM Ziplex® platform and is based on a patented flow through array technology. It provides for low cost, highly multiplexed, rapid and sensitive capture of targets from a wide variety of sample types. A proprietary chemistry approach (the HyCEAD method) allows for the capture and amplification of over 100 biomarkers simultaneously in a single reaction. The HyCEAD Ziplex system is extremely sensitive and is ideal for measuring gene expression and other markers directly from Parsortix harvests and was used in the ovarian cancer pelvic mass triage test to achieve best in class accuracy (ROC-AUC) of 95.1%.
ANGLE's proprietary technologies can be combined to provide automated, sample-to-answer results in both centralised laboratory and point-of-use cartridge formats.
ANGLE has established formal collaborations with world-class cancer centres and major corporates such as Abbott, Philips and QIAGEN, and works closely with leading CTC translational research customers. These Key Opinion Leaders (KOLs) are working to identify applications with medical utility (clear benefit to patients), and to secure clinical data that demonstrates that utility in patient studies. The body of evidence as to the benefits of the Parsortix system is growing rapidly from our own clinical studies in metastatic breast cancer and ovarian cancer and also from KOLs with 29 peer-reviewed publications and numerous publicly available posters, available on our website.
This information is provided by RNS, the news service of the
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