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ANGLE plc is a commercially driven specialist medical diagnostic company with pioneering products in cancer diagnostics and foetal health.


ANGLE plc’s lead product is the Parsortix cell separation system, which can capture very rare cells from blood. This includes circulating tumor cells (CTCs) in cancer patient blood – even when...

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ANGLE’s Novocellus starts EmbryoSure clinical trial

Novocellus reckons EmbryoSure has the potential to increase pregnancy rates by a quarter and possibly by as much as 40 per cent.

ANGLE (LON:AGL) said its 92 per cent held Novocellus business has started the clinical trial for the EmbryoSure product used in in-vitro fertilisation (IVF).

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved the amended EmbryoSure trial and patient recruitment starts this week.

Novocellus plans to recruit around 400 patients and the trial is scheduled for completion in mid-year 2013.  Product launch in the UK is anticipated in mid-year 2014.

Four leading UK IVF clinics are participating in the trial, namely: IVF Hammersmith Ltd at Hammersmith Hospital; CARE Fertility in Manchester, the UK's largest independent provider of assisted conception cycles; The Leeds Centre for Reproductive Medicine (LCRM) and the Hewitt Centre for Reproductive Medicine at Liverpool Women's NHS Foundation Trust.

Novocellus has a partnership with Danish group ORIGIO, a supplier of specialised IVF products. ORIGIO has the right to license the EmbryoSure intellectual property in exchange for milestone payments and a royalty on future net sales.

The business secured a second patent for EmbryoSure in the US, extending the period during which Novocellus would receive royalties.

If the EmbryoSure trials are successful, the royalty potential for Novocellus if the product is adopted across ORIGIO's entire existing customer base is circa £25 million per annum.

The impact of the second Novocellus patent granting will potentially translate into additional cumulative royalty income of more than £150 million to Novocellus.

The science behind the product was developed by the University of York, and it tests the amino acid profile of the culture medium used to carry the fertilised egg.  

ANGLE believes EmbryoSure will identify with 95 per cent confidence which one of the embryos is likely to be a top quartile embryo. Currently there is no such means of identifying the best eggs.

Novocellus reckons EmbryoSure has the potential to increase pregnancy rates by a quarter and possibly by as much as 40 per cent.

ANGLE operates as a specialist medical technology company with products in cancer diagnostics and fetal health, and it also owns a specialist technology consultancy.

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