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YM Biosciences’ Nimotuzamab selected for Phase III trial by Singapore

5th Jan 2009, 12:48 pm YM Biosciences’ Nimotuzamab selected for Phase III trial by Singapore

YM BioSciences Inc said the National Cancer Centre of Singapore (NCCS) has selected nimotuzumab, its epidermal growth factor receptor -targeting antibody, for evaluation in a multinational Phase III trial of more than 700 patients with cancers of the head and neck.


The NCCS stated that it selected nimotuzumab because of its reported preferential safety profile compared with other EGFR-targeting cancer drugs, the oncology group said.  The trial is sponsored by the NCCS in collaboration with Innogene Kalbiotech Pte Ltd, YM's licensee for nimotuzumab for the region.


The NCCS is the lead cancer centre coordinating this clinical trial, which will involve approximately 22 institutions from 12 countries worldwide.


 The primary endpoint for this study is two-year and five-year disease-free survival; the secondary endpoint is two-year and five-year overall survival.

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